Projects

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Inflammatory memory of muscle stem cells

We are investigating how epigenetic aging and inflammatory memory control the behaviour of muscle stem cells in the context of chronic disease. One consequence of these epigenetic changes could be priming stem cells toward pro- or anti-inflammatory phenotypes leading to faulty tissue repair. 

This work is supported by a Research and Development Grant).

The role of biological sex on

cardiac cachexia

Men and women exhibit robust differences in the pathophysiology of heart failure, which has long been overlooked in pre-clinical studies. Sex also impacts muscle mass. In heart failure, muscles erode, resulting in increased morbidity and mortality. We are studying molecular mediators of these differences using a mouse model of cardiac cachexia.