The Tobin Lab at Trent University
Projects
For a full list of publications, please see Dr. Tobin's Google Scholar page
Immune:muscle
cross-talk
We are investigating how aging and disease influence the communication between muscles (whole fibers or muscle stem cells) and immune cells. We do this using mouse and cell models.
Biological sex &Â cardiac cachexia
Men and women exhibit robust differences in the pathophysiology of heart failure, which has long been overlooked in pre-clinical studies. In heart failure, skeletal muscles weaken, resulting in increased morbidity and mortality. We are studying molecular mediators of these differences using a mouse model of cardiac cachexia.
tRNA modifications in
skeletal muscle
Modification of tRNA can have important consequences on how efficiently proteins are made. We are examining how modification of tRNA by TRIT1 influences both mitochondrial and cytosolic tRNA in skeletal muscle.
Funding
The Tobin Lab would like to thank the following funders for their financial support: NSERC Discovery Grant, NSERC Research Tools and Instruments Grant, NSERC Alliance International Grant, The Canadian Foundation for Innovation, the Ontario Research Fund (CFI-JELF) and Trent University.